Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9596403 | 1.00 | PTGS1 (0.41) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL8121822 | 0.98 | PTGS1 (0.42) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL8959530 | 0.93 | PTGS1 (0.43) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9334427 | 0.86 | PTGS1 (0.46) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9508949 | 0.83 | PTGS1 (0.43) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9334043 | 0.81 | S1PR2 (0.50) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9335603 | 0.81 | S1PR2 (0.50) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL9270441 | 0.81 | HTR2A (0.42) | PTGS1PTGS2LMNAESR1ADRB3 | |
| SCHEMBL9440807 | 0.80 | PTGS1 (0.47) | PTGS1PTGS2ALOX5LMNACYP2C9 | |
| SCHEMBL8119681 | 0.79 | S1PR2 (0.48) | PTGS1PTGS2ALOX5LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603278-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5312829-A | Testosterone 5alpha-reductase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-17 | — | — | US | disclosed |
| US-5212320-A | Enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| WO-1993005019-A1 | INDOLE DERIVATIVES AS 5-ALPHA-REDUCTASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-18 | — | — | WO | disclosed |