⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933842 | 0.91 | EGLN1 (0.53) | — | |
| SCHEMBL10009034 | 0.86 | — | — | |
| SCHEMBL10010789 | 0.86 | KDM4E (0.54) | — | |
| SCHEMBL933828 | 0.85 | HIF1A (0.48) | — | |
| SCHEMBL934455 | 0.85 | — | — | |
| SCHEMBL935489 | 0.83 | — | — | |
| SCHEMBL933679 | 0.83 | EGLN1 (0.54) | — | |
| SCHEMBL934250 | 0.82 | — | — | |
| SCHEMBL10009812 | 0.82 | — | — | |
| SCHEMBL934493 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102164905-B | Compounds, compositions, and uses thereof as hypoxia mimetics | BEIJING BETA PHARMA INC | 2014-04-30 | — | — | CN | claimed |
| EP-2454249-B1 | COMPOUNDS AS HYPOXIA MIMETICS, AND COMPOSITIONS, AND USES THEREOF | BEIJING BETTA PHARMACEUTICALS CO LTD (CN) | 2018-09-19 | — | — | EP | disclosed |
| US-8742138-B2 | Compounds as hypoxia mimetics, and compositions and uses thereof | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-06-03 | — | — | US | disclosed |
| CN-102164905-B | Compounds, compositions, and uses thereof as hypoxia mimetics | BEIJING BETA PHARMA INC | 2014-04-30 | — | — | CN | disclosed |
| US-20120172399-A1 | COMPOUNDS AS HYPOXIA MIMETICS, AND COMPOSIITONS AND USES THEREOF | BEIJING BETTA PHARMACEUTICALS CO., LTD. (CN) | 2012-07-05 | — | — | US | disclosed |
| EP-2454249-A1 | COMPOUNDS AS HYPOXIA MIMETICS, AND COMPOSITIONS, AND USES THEREOF | Zhejiang Beta Pharma Inc. (CN) | 2012-05-23 | — | — | EP | disclosed |
| CN-102164905-A | Compounds, compositions, and uses thereof as hypoxia mimetics | BEIJING BETA PHARMA INC | 2011-08-24 | — | — | CN | disclosed |
| WO-2011006355-A1 | COMPOUNDS AS HYPOXIA MIMETICS, AND COMPOSITIONS, AND USES THEREOF | BEIJING BETA PHARMA INC. (CN) | 2011-01-20 | — | — | WO | disclosed |