Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 17/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15407142 | 0.93 | MAP3K5 (0.59) | MAP3K5MEN1KMT2A | |
| SCHEMBL15407592 | 0.92 | MAP3K5 (0.60) | MAP3K5TNF | |
| SCHEMBL20523096 | 0.89 | MAP3K5 (0.54) | MAP3K5TNF | |
| SCHEMBL20523038 | 0.89 | MAP3K5 (0.52) | MAP3K5TNF | |
| SCHEMBL15408170 | 0.89 | MAP3K5 (0.67) | MAP3K5MEN1KMT2A | |
| SCHEMBL20522708 | 0.87 | MAP3K5 (0.57) | MAP3K5 | |
| Hydrochloric Acid SCHEMBL20523105 | 0.86 | MAP3K5 (0.56) | MAP3K5 | |
| SCHEMBL15408664 | 0.84 | MAP3K5 (0.54) | MAP3K5 | |
| SCHEMBL946130 | 0.83 | MAP3K5 (0.52) | MAP3K5KMT2ATNF | |
| SCHEMBL29265532 | 0.83 | NPC1 (0.56) | MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |