SCHEMBL9341872

SCHEMBL9341872

CCCCCCCCc1ccc(-c2cnc(-c3ccc(CCCCC)cc3)nc2)c(F)c1F

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.58
ALDH1A1 P00352 3/20 0.58
RAB9A P51151 3/20 0.58
SMN1; SMN2 Q16637 3/20 0.58
HSD17B10 Q99714 3/20 0.58
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
KDM4E B2RXH2 2/20 0.58
USP2 O75604 1/20 0.58
GAA P10253 1/20 0.58
HPGD P15428 1/20 0.58
RARB P10826 10/20 0.48
RARA P10276 2/20 0.41
MTOR P42345 1/20 0.41
NPC1 O15118 2/20 0.40
STAT3 P40763 1/20 0.40
ATM Q13315 1/20 0.40
SPHK1 Q9NYA1 1/20 0.40
HSD11B1 P28845 1/20 0.39
RARG P13631 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9406137 0.91 RARB (0.55) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9406131 0.91 RARB (0.55) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9342525 0.91 RARB (0.55) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9405682 0.91 RARB (0.55) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9406333 0.90 RARB (0.54) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9405879 0.88 RARB (0.54) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9493678 0.85 RARB (0.51) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9493545 0.85 RARB (0.51) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9486831 0.85 RARB (0.51) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9494212 0.85 RARB (0.51) MAPTALDH1A1RAB9ASMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0373191-B1 HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES MERCK PATENT GMBH (DE) 1994-07-13 EP disclosed
US-5209866-A HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-05-11 US disclosed
EP-0373191-A1 HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES. MERCK PATENT GMBH (DE) 1990-06-20 EP disclosed
WO-1989008649-A1 HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1989-09-21 WO disclosed
EP-0332024-A1 Heterocyclic derivatives of 1,2-difluorobenzene MERCK PATENT GmbH (DE) 1989-09-13 EP disclosed