Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572350 | 0.95 | — | — | |
| SCHEMBL8984907 | 0.86 | — | — | |
| SCHEMBL7572909 | 0.84 | — | — | |
| SCHEMBL7569944 | 0.84 | — | — | |
| SCHEMBL7567922 | 0.83 | — | — | |
| SCHEMBL7566112 | 0.82 | — | — | |
| SCHEMBL7565223 | 0.81 | — | — | |
| SCHEMBL7108735 | 0.81 | — | — | |
| SCHEMBL7567375 | 0.81 | — | — | |
| SCHEMBL7108644 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288757-A | Aminosulfonyl urea ACAT inhibitors and a method of lowering blood cholesterol levels therewith | WARNER-LAMBERT COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0556322-A1 | AMINOSULFONYL UREA ACAT INHIBITORS. | WARNER LAMBERT CO (US) | 1993-08-25 | — | — | EP | disclosed |
| US-5214206-A | Anticholesterol agents, inhibitors of acylcoenzyme A | WARNER-LAMBERT COMPANY (US) | 1993-05-25 | — | — | US | disclosed |
| WO-1992008694-A1 | AMINOSULFONYL UREA ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1992-05-29 | — | — | WO | disclosed |