Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.66 |
| ▸ | CNR2 | P34972 | 6/20 | 0.60 |
| ▸ | CNR1 | P21554 | 4/20 | 0.60 |
| ▸ | HTR7 | P34969 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540544 | 0.97 | PLK1 (0.66) | PLK1CNR2CNR1HTR7KDM4E | |
| SCHEMBL548607 | 0.92 | CNR2 (0.70) | PLK1CNR2CNR1KDM4EALDH1A1 | |
| SCHEMBL9340471 | 0.92 | CNR2 (0.70) | PLK1CNR2CNR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2035939 | 0.91 | CNR2 (0.68) | PLK1CNR2CNR1KDM4EALDH1A1 | |
| SCHEMBL12643110 | 0.91 | CNR2 (0.69) | PLK1CNR2CNR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2041733 | 0.89 | CNR2 (0.67) | PLK1CNR2CNR1KDM4EALDH1A1 | |
| SCHEMBL5450086 | 0.86 | CNR2 (0.62) | PLK1CNR2CNR1HTR7ALDH1A1 | |
| SCHEMBL6870502 | 0.82 | CNR1 (0.71) | CNR2CNR1 | |
| SCHEMBL11903673 | 0.81 | CNR2 (0.74) | CNR2CNR1 | |
| SCHEMBL31052987 | 0.81 | CNR2 (0.74) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600955-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993003725-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-04 | — | — | WO | disclosed |