SCHEMBL9344377

SCHEMBL9344377

CCC[C@H]1CC[C@H](CCCOc2ccc(-c3ccc(OCCC[C@H]4CC[C@H](CCC)CC4)cc3)cc2)CC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 6/20 0.50
CYP3A4 P08684 4/20 0.50
CYP19A1 P11511 5/20 0.46
CYP2C9 P11712 5/20 0.46
CYP2C19 P33261 5/20 0.46
CYP1A2 P05177 4/20 0.46
HRH3 Q9Y5N1 3/20 0.46
RARB P10826 4/20 0.44
NFE2L2 Q16236 1/20 0.42
RAB9A P51151 4/20 0.41
NPC1 O15118 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HSD17B10 Q99714 1/20 0.41
KDM4E B2RXH2 1/20 0.41
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
NLRP3 Q96P20 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
HRH2 P25021 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9344385 1.00 CYP2D6 (0.50) CYP2D6CYP3A4CYP19A1CYP2C9CYP2C19
SCHEMBL9345208 0.95 CYP2D6 (0.50) CYP2D6CYP3A4CYP19A1CYP2C9CYP2C19
SCHEMBL9345222 0.95 CYP2D6 (0.50) CYP2D6CYP3A4CYP19A1CYP2C9CYP2C19
SCHEMBL9344601 0.95 HRH3 (0.49) CYP2D6CYP3A4CYP2C19CYP1A2HRH3
SCHEMBL9344596 0.95 HRH3 (0.49) CYP2D6CYP3A4CYP2C19CYP1A2HRH3
SCHEMBL9346152 0.93 CYP2D6 (0.54) CYP2D6CYP3A4CYP19A1CYP2C9CYP2C19
SCHEMBL9346140 0.93 CYP2D6 (0.54) CYP2D6CYP3A4CYP19A1CYP2C9CYP2C19
SCHEMBL9344251 0.93 HRH3 (0.48) CYP2D6CYP3A4HRH3NFE2L2RAB9A
SCHEMBL9344264 0.93 HRH3 (0.48) CYP2D6CYP3A4HRH3NFE2L2RAB9A
SCHEMBL9346096 0.92 CYP2D6 (0.44) CYP2D6CYP3A4CYP19A1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0344557-B1 Liquid crystal components with a trimethylenoxy group HOFFMANN LA ROCHE (CH) 1994-08-10 EP disclosed
US-5238600-A IBIMETHYLENOXY CONTAINING LIQUID CRYSTAL COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 1993-08-24 US disclosed
EP-0344557-A2 Liquid crystal components with a trimethylenoxy group F. HOFFMANN-LA ROCHE AG (CH) 1989-12-06 EP disclosed