Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 15/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.71 |
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | HTR2C | P28335 | 2/20 | 0.71 |
| ▸ | HRH1 | P35367 | 2/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.71 |
| ▸ | HTR2B | P41595 | 2/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9347628 | 1.00 | SLC6A4 (0.75) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9348316 | 1.00 | SLC6A4 (0.75) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9347627 | 0.99 | SLC6A4 (0.73) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9347445 | 0.99 | SLC6A4 (0.73) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL9347623 | 0.99 | SLC6A4 (0.73) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21118565 | 0.86 | SLC6A4 (0.73) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30501482 | 0.84 | SLC6A4 (0.71) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8082370 | 0.84 | SLC6A4 (0.71) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4623634 | 0.84 | SLC6A4 (0.71) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24177878 | 0.84 | SLC6A4 (0.56) | SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5320825-A | Psychological disorders | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1994-06-14 | — | — | US | claimed |
| US-5320825-A | Psychological disorders | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1994-06-14 | — | — | US | disclosed |
| WO-1992019210-A2 | SEROTININ REUPTAKE INHIBITORS FOR S.P.E.C.T IMAGING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1992-11-12 | — | — | WO | disclosed |