Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10388746 | 0.83 | KDM4E (0.57) | KDM4ECYP19A1SIGMAR1DRD2HTR2A | |
| SCHEMBL10346131 | 0.82 | KDM4E (0.55) | KDM4ECYP19A1SIGMAR1DRD2HTR2A | |
| SCHEMBL9345561 | 0.81 | KDM4E (0.49) | KDM4ECYP19A1SIGMAR1DRD2HTR2A | |
| SCHEMBL11733442 | 0.80 | PPARG (0.45) | SIGMAR1ALDH1A1TSHR | |
| SCHEMBL2139852 | 0.78 | KDM4E (0.49) | KDM4ECYP19A1SIGMAR1DRD2HTR2A | |
| SCHEMBL15294423 | 0.77 | KDM4E (0.64) | KDM4ECYP19A1SIGMAR1DRD2HTR2A | |
| SCHEMBL10389080 | 0.75 | KDM4E (0.48) | KDM4ECYP19A1SIGMAR1HTR2CNPC1 | |
| SCHEMBL10450126 | 0.74 | KDM4E (0.45) | KDM4ECYP19A1SIGMAR1DRD2HTR2A | |
| SCHEMBL10448555 | 0.74 | KDM4E (0.45) | KDM4ECYP19A1SIGMAR1DRD2HTR2A | |
| SCHEMBL9280515 | 0.73 | KDM4E (0.49) | KDM4ECYP19A1SIGMAR1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5288752-A | Brain disorders | SUNTORY LIMITED (JP) | 1994-02-22 | — | — | US | disclosed |
| EP-0322248-B1 | COMPOUNDS EFFECTIVE AGAINST CEREBRAL INSUFFICIENCY | SUNTORY LIMITED (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5179092-A | Cognition activators | SUNTORY LIMITED (JP) | 1993-01-12 | — | — | US | disclosed |
| EP-0181145-B1 | HETEROCYCLIC COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-31 | — | — | EP | disclosed |
| EP-0322248-A2 | Compounds effective against cerebral insufficiency | SUNTORY LIMITED (JP) | 1989-06-28 | — | — | EP | disclosed |
| US-4755511-A | Tricyclic pyridazinone compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-07-05 | — | — | US | disclosed |
| EP-0181145-A2 | Heterocyclic compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-05-14 | — | — | EP | disclosed |