Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.71 |
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.71 |
| ▸ | HTR2B | P41595 | 1/20 | 0.71 |
| ▸ | CASP3 | P42574 | 1/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 12/20 | 0.62 |
| ▸ | GAA | P10253 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylamine SCHEMBL21145246 | 0.91 | HSD17B10 (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL29736617 | 0.91 | HSD17B10 (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL21145247 | 0.91 | HSD17B10 (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL28222060 | 0.90 | HSD17B10 (0.92) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL28374444 | 0.88 | HSD17B10 (0.67) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL6904395 | 0.88 | MAPT (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL4428609 | 0.88 | MAPT (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL374606 | 0.88 | MAPT (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL28553827 | 0.88 | MAPT (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 | |
| Diphenylamine SCHEMBL27511663 | 0.88 | MAPT (0.71) | HSD17B10ALDH1A1TSHRMAPK1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113526457-B | Needle tip-adhesive film combined transfer device and method for nano material | 中国科学院物理研究所 | 2023-07-21 | — | — | CN | disclosed |
| CN-113526457-A | Needle point-adhesive film combined transfer device and method for nano materials | 中国科学院物理研究所 | 2021-10-22 | — | — | CN | disclosed |
| US-5296602-A | Condensing substituted ortho-halo- or ortho-aminobenzoic acid with meta-halo- or meta-aminoanisole, cyclizing, N-alkylating, de-O-methylating | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1994-03-22 | — | — | US | disclosed |
| WO-1992016509-A1 | MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-10-01 | — | — | WO | disclosed |