Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL9348688

N.c1ccc(COC[C@H]2NC[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)cc1

nearest known ligand 0.92

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
BCHE P06276 4/20 0.92
ACHE P22303 2/20 0.92
LMNA P02545 1/20 0.42
TSHR P16473 1/20 0.39
PDE4D Q08499 1/20 0.38
HTR1A P08908 1/20 0.37
PDPK1 O15530 1/20 0.37
MTOR P42345 1/20 0.37
MAN2A1 Q16706 1/20 0.37
MAN1B1 Q9UKM7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL10444883 1.00 BCHE (0.92) BCHEACHELMNATSHRPDE4D
SCHEMBL12164680 0.99 BCHE (0.94) BCHEACHELMNATSHRPDE4D
SCHEMBL8715956 0.99 BCHE (0.94) BCHEACHELMNATSHRPDE4D
SCHEMBL10444884 0.99 BCHE (0.94) BCHEACHELMNATSHRPDE4D
SCHEMBL6251358 0.99 BCHE (0.94) BCHEACHELMNATSHRPDE4D
SCHEMBL8715953 0.99 BCHE (0.94) BCHEACHELMNATSHRPDE4D
SCHEMBL11464350 0.96 BCHE (1.00) BCHEACHELMNATSHRPDE4D
SCHEMBL31103765 0.96 BCHE (1.00) BCHEACHELMNATSHRPDE4D
SCHEMBL13777996 0.96 BCHE (1.00) BCHEACHELMNATSHRPDE4D
SCHEMBL20680384 0.96 BCHE (1.00) BCHEACHELMNATSHRPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0422975-B1 Alpha-glucosidase inhibitors MERRELL DOW PHARMA (US) 1994-07-27 EP disclosed
EP-0422975-A1 Alpha-glucosidase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1991-04-17 EP disclosed
EP-0422307-A1 Novel alpha-glucosidase inhibitors MERRELL DOW PHARMACEUTICALS INC. (US) 1991-04-17 EP disclosed