Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9353372 | 0.99 | ACE (0.43) | ACEDPP4DPP8DPP9DPP7 | |
| SCHEMBL9353285 | 0.98 | DPP8 (0.42) | ACEDPP4DPP8DPP9DPP7 | |
| SCHEMBL9353532 | 0.96 | ACE (0.40) | ACEDPP4DPP8DPP9DPP7 | |
| SCHEMBL9357495 | 0.92 | SIRT2 (0.41) | DPP4DPP8DPP9DPP7REN | |
| SCHEMBL9353588 | 0.92 | SIRT2 (0.41) | DPP4DPP8DPP9DPP7REN | |
| SCHEMBL10430251 | 0.92 | DPP8 (0.40) | DPP4DPP8DPP9DPP7REN | |
| SCHEMBL10430255 | 0.88 | DPP8 (0.41) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL474142 | 0.86 | ACE (0.58) | ACE | |
| SCHEMBL9353717 | 0.85 | ACE (0.57) | ACE | |
| SCHEMBL9353731 | 0.85 | DPP8 (0.42) | ACEDPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0350138-B1 | Processes for preparing phosphonyl hydroxyacyl prolines | SQUIBB & SONS INC (US) | 1994-10-19 | — | — | EP | disclosed |
| EP-0229520-B1 | ORALLY ACTIVE PHOSPHONYL HYDROXYACYL PROLINES AND PROCESSES FOR PREPARING PHOSPHONYL HYDROXYACYL PROLINES | E.R. Squibb & Sons, Inc. (US) | 1990-05-30 | — | — | EP | disclosed |
| US-4900860-A | Process for preparing phosphonyloxyacyl amino acids | E. R. SQUIBB & SONS, INC. (US) | 1990-02-13 | — | — | US | disclosed |
| EP-0350138-A2 | Processes for preparing phosphonyl hydroxyacyl prolines | E.R. SQUIBB & SONS, INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| US-4885380-A | REACTING PHOSPHONIC ACID DICHLORIDE WITH ALPHA-HYDROXY ACID TO FORM CYCLIC MIXED ANHYDRIDE; REACTING WITH AMINO ACID | THOTTATHIL JOHN K (US) | 1989-12-05 | — | — | US | disclosed |
| US-4745196-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1988-05-17 | — | — | US | disclosed |
| EP-0237264-A2 | Process for preparing phosphonyloxyacyl amino acids and derivates thereof | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |
| EP-0229520-A1 | Orally active phosphonyl hydroxyacyl prolines and processes for preparing phosphonyl hydroxyacyl prolines | E.R. Squibb & Sons, Inc. (US) | 1987-07-22 | — | — | EP | disclosed |