Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9349978 | 0.98 | AOC3 (0.42) | AOC3GAAADRB2PSEN1PSEN2 | |
| SCHEMBL9349974 | 0.83 | PSEN1 (0.40) | AOC3GAAADRB2PSEN1PSEN2 | |
| SCHEMBL3185372 | 0.80 | AOC3 (0.52) | AOC3GAABRD4LMNADRD4 | |
| SCHEMBL8115632 | 0.80 | AOC3 (0.52) | AOC3GAABRD4LMNADRD4 | |
| SCHEMBL8113426 | 0.80 | AOC3 (0.52) | AOC3GAABRD4LMNADRD4 | |
| SCHEMBL29571171 | 0.77 | AOC3 (0.55) | AOC3GAAADRB2BRD4SLC6A2 | |
| SCHEMBL12243879 | 0.76 | AOC3 (0.53) | AOC3GAAADRB2BRD4SLC6A2 | |
| SCHEMBL29700206 | 0.75 | AOC3 (0.55) | AOC3GAAADRB2BRD4LMNA | |
| SCHEMBL28695977 | 0.74 | AOC3 (0.41) | AOC3GAATRPA1LMNASMN1; SMN2 | |
| SCHEMBL21363396 | 0.74 | AOC3 (0.47) | AOC3GAAADRB2BRD4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293220-B1 | Pharmacologically active 2-and 3-substituted (1', 5'-diaryl-3-pyrazolyl)-N-Hydroxypropanamides and method for synthesizing | ORTHO PHARMA CORP (US) | 1994-08-31 | — | — | EP | claimed |