Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 9/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.66 |
| ▸ | CDK8 | P49336 | 5/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.66 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.66 |
| ▸ | MELK | Q14680 | 3/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.55 |
| ▸ | PRKACA | P17612 | 7/20 | 0.52 |
| ▸ | CDK2 | P24941 | 6/20 | 0.52 |
| ▸ | HIPK2 | Q9H2X6 | 6/20 | 0.52 |
| ▸ | CLK2 | P49760 | 3/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.52 |
| ▸ | CDK7 | P50613 | 3/20 | 0.52 |
| ▸ | CDK9 | P50750 | 3/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935432 | 0.91 | CDC7 (0.76) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL1043016 | 0.88 | CDC7 (0.85) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL1046336 | 0.79 | CDC7 (1.00) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL934735 | 0.75 | CDC7 (0.47) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL12707482 | 0.75 | MAPK1 (0.48) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL968641 | 0.74 | CDC7 (0.50) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL934923 | 0.74 | CDC7 (0.74) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL30208810 | 0.72 | MAPK1 (0.72) | DYRK1ADYRK1BROCK2LRRK2ROCK1 | |
| SCHEMBL1045884 | 0.71 | CDC7 (0.77) | CDC7CLK4CDK8DYRK1AMAP4K4 | |
| SCHEMBL1045438 | 0.71 | CDC7 (1.00) | CDC7CLK4CDK8DYRK1AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454262-B1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LAB (US) | 2014-05-14 | — | — | EP | claimed |
| US-8383624-B2 | Pyrrolopyrazine inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | claimed |
| EP-2454262-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | claimed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | claimed |
| WO-2011008830-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | claimed |
| EP-2454262-B1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LAB (US) | 2014-05-14 | — | — | EP | disclosed |
| US-8383624-B2 | Pyrrolopyrazine inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2454262-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2011008830-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | CDC7, CDK7, CDK17 | CDC7 1/4885CLK4 347/4885CDK8 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.