Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 4/20 | 0.43 |
| ▸ | CES1 | P23141 | 4/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.40 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841841 | 0.86 | KMT2A (0.52) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL8899231 | 0.82 | CES1 (0.33) | KMT2AMAPTCES2CES1AKR1B1 | |
| SCHEMBL96401 | 0.77 | KMT2A (0.50) | KMT2AMAPTCES2CES1AKR1B1 | |
| SCHEMBL2345888 | 0.77 | TDP1 (0.41) | KMT2AAKR1B1GPR84PPARGPPARD | |
| SCHEMBL2352324 | 0.77 | TDP1 (0.41) | KMT2AAKR1B1GPR84PPARGPPARD | |
| SCHEMBL8896261 | 0.76 | KMT2A (0.50) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL2349524 | 0.73 | TDP1 (0.48) | KMT2AAKR1B1GPR84PPARGPPARD | |
| SCHEMBL2348671 | 0.73 | TDP1 (0.48) | KMT2AAKR1B1GPR84PPARGPPARD | |
| SCHEMBL19617979 | 0.72 | KMT2A (0.56) | KMT2AMAPTCES2CES1HAO1 | |
| SCHEMBL2994225 | 0.72 | KMT2A (0.56) | KMT2AMAPTCES2CES1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310321-B1 | Immunomodulatory azaspiranes | SMITHKLINE BEECHAM CORP (US) | 1994-11-30 | — | — | EP | disclosed |