Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.57 |
| ▸ | GSK3B | P49841 | 4/20 | 0.57 |
| ▸ | CDK2 | P24941 | 11/20 | 0.46 |
| ▸ | CDK9 | P50750 | 11/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.46 |
| ▸ | CCNK | O75909 | 9/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.45 |
| ▸ | PAK4 | O96013 | 3/20 | 0.45 |
| ▸ | PRKACA | P17612 | 3/20 | 0.45 |
| ▸ | CDK8 | P49336 | 3/20 | 0.45 |
| ▸ | PRKX | P51817 | 3/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.45 |
| ▸ | STK3 | Q13188 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | MELK | Q14680 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934236 | 0.88 | CDC7 (0.71) | CDC7GSK3BCDK2CDK9ROCK2 | |
| SCHEMBL1045663 | 0.85 | CDC7 (0.80) | CDC7GSK3BCDK2CDK9CCNT1 | |
| SCHEMBL935168 | 0.83 | CDC7 (0.58) | CDC7GSK3BCDK2CDK9ROCK2 | |
| SCHEMBL935166 | 0.83 | CDC7 (0.58) | CDC7GSK3BCDK2CDK9ROCK2 | |
| SCHEMBL1014568 | 0.82 | CDC7 (0.56) | CDC7GSK3BCDK2CDK9ROCK2 | |
| SCHEMBL935164 | 0.82 | CDC7 (0.55) | CDC7GSK3BCDK2CDK9CCNT1 | |
| SCHEMBL6128670 | 0.81 | CDC7 (0.54) | CDC7GSK3BCDK2CDK9ROCK2 | |
| SCHEMBL935124 | 0.79 | CDC7 (0.52) | CDC7GSK3BCDK2CDK9CCNT1 | |
| SCHEMBL14713224 | 0.79 | CDC7 (0.54) | CDC7GSK3BCDK2CDK9ROCK2 | |
| SCHEMBL934386 | 0.79 | CDC7 (0.56) | CDC7GSK3BCDK2CDK9ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454262-B1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LAB (US) | 2014-05-14 | — | — | EP | claimed |
| US-8383624-B2 | Pyrrolopyrazine inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | claimed |
| EP-2454262-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | claimed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | claimed |
| WO-2011008830-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | claimed |
| EP-2454262-B1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LAB (US) | 2014-05-14 | — | — | EP | disclosed |
| US-8383624-B2 | Pyrrolopyrazine inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2454262-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2011008830-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015172-A1 | PYRROLOPYRAZINE INHIBITORS OF KINASES | CDC7, CDK7, CDK17 | CDC7 1/4885GSK3B 307/4885CDK2 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.