Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 18/20 | 0.73 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923731 | 0.97 | PRKD1 (0.70) | PRKD1PRKD3PRKD2MAP4K1CTSK | |
| SCHEMBL936515 | 0.85 | PRKD1 (1.00) | PRKD1CTSK | |
| SCHEMBL936600 | 0.83 | PRKD1 (1.00) | PRKD1PRKD3PRKD2MAP4K1 | |
| SCHEMBL936598 | 0.83 | PRKD1 (1.00) | PRKD1PRKD3PRKD2MAP4K1 | |
| SCHEMBL958404 | 0.82 | PRKD1 (0.85) | PRKD1PRKD3PRKD2CTSK | |
| SCHEMBL6923010 | 0.82 | PRKD1 (0.73) | PRKD1MAP4K1 | |
| SCHEMBL6923791 | 0.82 | PRKD1 (0.95) | PRKD1CTSK | |
| SCHEMBL957994 | 0.82 | PRKD1 (0.81) | PRKD1PRKD3PRKD2MAP4K1 | |
| SCHEMBL937242 | 0.80 | PRKD1 (0.70) | PRKD1MAP4K1 | |
| SCHEMBL958900 | 0.79 | PRKD1 (0.77) | PRKD1PRKD3PRKD2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |