Terephthalamide

Terephthalamide

SCHEMBL9363256

NC(=O)c1ccc(C(N)=O)cc1.Nc1ccc(NC(=O)c2ccc(N)cc2)cc1

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.85
POLB P06746 2/20 0.85
MEN1 O00255 2/20 0.85
LMNA P02545 1/20 0.85
PKM P14618 1/20 0.85
APEX1 P27695 1/20 0.85
TDP1 Q9NUW8 1/20 0.85
PTGS1 P23219 2/20 0.67
MAPT P10636 3/20 0.65
CA12 O43570 1/20 0.65
CA1 P00915 1/20 0.65
CA2 P00918 1/20 0.65
CA9 Q16790 1/20 0.65
BCAT2 O15382 1/20 0.60
RAB9A P51151 5/20 0.59
NPC1 O15118 4/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
TP53 P04637 1/20 0.59
KDM4E B2RXH2 1/20 0.59
SNCA P37840 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14972618 1.00 KMT2A (0.85) KMT2APOLBMEN1LMNAPKM
SCHEMBL3282206 1.00 KMT2A (0.85) KMT2APOLBMEN1LMNAPKM
SCHEMBL13210699 0.92 KMT2A (0.73) KMT2APOLBMEN1LMNAPKM
SCHEMBL9681496 0.92 POLB (1.00) KMT2APOLBMEN1LMNAPKM
SCHEMBL1353478 0.92 POLB (1.00) KMT2APOLBMEN1LMNAPKM
SCHEMBL30319980 0.92 POLB (1.00) KMT2APOLBMEN1LMNAPKM
SCHEMBL2128727 0.92 POLB (1.00) KMT2APOLBMEN1LMNAPKM
SCHEMBL137276 0.92 POLB (1.00) KMT2APOLBMEN1LMNAPKM
SCHEMBL8442129 0.90 POLB (0.96) KMT2APOLBMEN1LMNAPKM
Hydrochloric Acid SCHEMBL8640632 0.90 POLB (0.96) KMT2APOLBMEN1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0168879-B1 PROCESS FOR THE MANUFACTURE OF FILAMENTS FROM AROMATIC POLYAMIDES AKZO N.V. (NL) 1988-08-17 EP claimed
JP-62079226-A None JP disclosed
EP-0445673-B1 Aromatic copolyamides, process for preparing them, and moulded articles therefrom HOECHST AG (DE) 1994-11-02 EP disclosed
EP-0424860-B1 Wholly aromatic polyamides, process for their preparation and products therefrom HOECHST AG (DE) 1993-12-01 EP disclosed
EP-0364892-B1 WHOLLY AROMATIC POLYAMIDES, PROCESS FOR PRODUCING THE SAME AND SHAPED ARTICLES HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-09 EP disclosed
EP-0364893-B1 WHOLLY AROMATIC POLYAMIDES, PROCESS FOR PRODUCING THE SAME AND SHAPED ARTICLES HOECHST AKTIENGESELLSCHAFT (DE) 1993-05-19 EP disclosed
EP-0445673-A2 Aromatic copolyamides, process for preparing them, and moulded articles therefrom HOECHST AKTIENGESELLSCHAFT (DE) 1991-09-11 EP disclosed
EP-0424860-A2 Wholly aromatic polyamides, process for their preparation and products therefrom HOECHST AKTIENGESELLSCHAFT (DE) 1991-05-02 EP disclosed
US-4987216-A Filaments, fibers, films, sheets, membranes of very high initial modulus HOECHST AKTIENGESELLSCHAFT (DE) 1991-01-22 US disclosed
EP-0364893-A2 Wholly aromatic polyamides, process for producing the same and shaped articles HOECHST AKTIENGESELLSCHAFT (DE) 1990-04-25 EP disclosed
EP-0364892-A2 Wholly aromatic polyamides, process for producing the same and shaped articles HOECHST AKTIENGESELLSCHAFT (DE) 1990-04-25 EP disclosed
US-4868041-A AROMATIC POLYAMIDES, COMPOSITES YARNS, CORES TOYO BOSEKI KABUSHIKI KAISHA (JP) 1989-09-19 US disclosed
EP-0218269-B1 FIBRES AND YARNS FROM A BLEND OF AROMATIC POLYAMIDES AKZO N.V. (NL) 1989-04-12 EP disclosed
EP-0168879-B1 PROCESS FOR THE MANUFACTURE OF FILAMENTS FROM AROMATIC POLYAMIDES AKZO N.V. (NL) 1988-08-17 EP disclosed
US-4721755-A Fibers and yarns from a blend of aromatic polyamides AKZO NV (NL) 1988-01-26 US disclosed
US-4702876-A EXTRUSION THROUGH AIRGAP, PASSAGE THROUGH LIQUID AKZO N.V. (NL) 1987-10-27 US disclosed
JP-S6279226-A PRODUCTION OF SURFACE-MODIFIED WHOLLY AROMATIC POLYAMIDE ASAHI CHEM IND CO LTD 1987-04-11 JP disclosed
EP-0168879-A1 Process for the manufacture of filaments from aromatic polyamides AKZO N.V. (NL) 1986-01-22 EP disclosed