Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 9/20 | 0.53 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951651 | 0.74 | MELK (0.79) | MELKPRKD1MAP4K1FLT3AURKA | |
| SCHEMBL28977159 | 0.74 | MELK (0.82) | MELKPRKD1MAP4K1MAPK1FLT3 | |
| SCHEMBL28977172 | 0.74 | MELK (0.86) | MELKPRKD1MAP4K1FLT3AURKA | |
| SCHEMBL28977186 | 0.73 | MELK (0.77) | MELKPRKD1MAP4K1JAK2 | |
| SCHEMBL30775205 | 0.73 | KDR (0.49) | MELKPARP1FLT3AURKAKDR | |
| SCHEMBL998233 | 0.72 | PRKD1 (0.74) | MELKPRKD1MAP4K1FLT3AURKA | |
| SCHEMBL1081001 | 0.72 | PRKD1 (0.73) | MELKPRKD1MAP4K1FLT3AURKA | |
| SCHEMBL27741315 | 0.71 | MELK (0.73) | MELKPRKD1MAP4K1 | |
| SCHEMBL28977183 | 0.71 | MELK (0.76) | MELKPRKD1MAP4K1FLT3AURKA | |
| SCHEMBL28977178 | 0.71 | MELK (0.72) | MELKPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |