Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20506587 | 0.83 | KDM4E (0.43) | BRD4POLBSMN1; SMN2IDO1TDO2 | |
| SCHEMBL29897761 | 0.83 | KDM4E (0.43) | BRD4POLBSMN1; SMN2IDO1TDO2 | |
| SCHEMBL22864551 | 0.80 | BRD4 (0.53) | BRD4OPRM1POLBADCY8SMN1; SMN2 | |
| SCHEMBL29800901 | 0.80 | BRD4 (0.53) | BRD4OPRM1POLBADCY8SMN1; SMN2 | |
| SCHEMBL6448185 | 0.78 | BRD4 (0.39) | BRD4SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL29897781 | 0.78 | BRD4 (0.39) | BRD4SMN1; SMN2GAAALDH1A1MAPT | |
| SCHEMBL22864629 | 0.76 | BRD4 (0.38) | BRD4POLBSMN1; SMN2IDO1TDO2 | |
| SCHEMBL22864673 | 0.74 | BRD4 (0.37) | BRD4POLBSMN1; SMN2IDO1TDO2 | |
| SCHEMBL31378040 | 0.74 | BRD4 (0.37) | BRD4POLBSMN1; SMN2IDO1TDO2 | |
| SCHEMBL8566418 | 0.73 | BRD4 (0.55) | BRD4OPRM1POLBSMN1; SMN2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287196-B1 | Indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| US-4920127-A | TREATMENT OF MIGRAINE, TRIGEMINAL NEURALGIA | BEECHAM GROUP P.L.C. (GB) | 1990-04-24 | — | — | US | disclosed |
| EP-0287196-A1 | Indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-10-19 | — | — | EP | disclosed |