Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 18/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936584 | 1.00 | PRKD1 (0.60) | PRKD1PRKD3PRKD2RAF1BRAF | |
| SCHEMBL962934 | 0.86 | PRKD1 (0.71) | PRKD1PRKD3PRKD2 | |
| SCHEMBL962933 | 0.86 | PRKD1 (0.71) | PRKD1PRKD3PRKD2 | |
| SCHEMBL1001130 | 0.83 | PRKD1 (0.73) | PRKD1PRKD3PRKD2 | |
| SCHEMBL1001131 | 0.83 | PRKD1 (0.73) | PRKD1PRKD3PRKD2 | |
| SCHEMBL936613 | 0.72 | PRKD1 (0.74) | PRKD1PRKD3PRKD2 | |
| SCHEMBL936126 | 0.72 | PRKD1 (0.81) | PRKD1 | |
| SCHEMBL967019 | 0.70 | PRKD1 (1.00) | PRKD1PRKD3PRKD2 | |
| SCHEMBL936439 | 0.69 | PRKD1 (1.00) | PRKD1PRKD3PRKD2 | |
| SCHEMBL6924103 | 0.69 | PRKD1 (1.00) | PRKD1PRKD3PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |