Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 13/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 5/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366617 | 1.00 | KDM1A (0.42) | KDM1AGRM2CYP11B1CYP11B2KDM4E | |
| SCHEMBL9366249 | 0.86 | GRIA2 (0.38) | KDM1ACYP11B1CYP11B2NPC1MAOB | |
| SCHEMBL9366242 | 0.86 | GRIA2 (0.38) | KDM1ACYP11B1CYP11B2NPC1MAOB | |
| SCHEMBL9732702 | 0.86 | KDM1A (0.41) | KDM1AGRM2CYP11B1CYP11B2KDM4E | |
| SCHEMBL9366647 | 0.86 | KDM1A (0.41) | KDM1AGRM2CYP11B1CYP11B2KDM4E | |
| SCHEMBL9366637 | 0.86 | KDM1A (0.41) | KDM1AGRM2CYP11B1CYP11B2KDM4E | |
| SCHEMBL9732698 | 0.86 | KDM1A (0.41) | KDM1AGRM2CYP11B1CYP11B2KDM4E | |
| SCHEMBL9365271 | 0.85 | KDM1A (0.38) | KDM1AGRM2CYP11B1CYP11B2KDM4E | |
| SCHEMBL9365278 | 0.85 | KDM1A (0.38) | KDM1AGRM2CYP11B1CYP11B2KDM4E | |
| SCHEMBL9365229 | 0.84 | KDM1A (0.50) | KDM1AKDM4ENPC1RAB9AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433835-B1 | Dioxanylpyridines | HOFFMANN LA ROCHE (CH) | 1994-05-18 | — | — | EP | disclosed |
| US-5160661-A | DIOXANYLPYRIDINE | HOFFMANN-LA ROCHE INC. (US) | 1992-11-03 | — | — | US | disclosed |
| EP-0433835-A2 | Dioxanylpyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |