Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.50 |
| ▸ | PDE4A | P27815 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9371436 | 0.86 | PDE3B (0.57) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9367616 | 0.80 | PDE3B (0.57) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9368143 | 0.80 | PDE3B (0.52) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9367283 | 0.80 | PDE3B (0.52) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9372484 | 0.79 | PDE3B (0.62) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9367299 | 0.79 | PDE3B (0.56) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9367690 | 0.79 | PDE3B (0.56) | PDE3BPDE3APDE4BPDE4APDE4C | |
| Hydrochloric Acid SCHEMBL10333797 | 0.78 | PDE3B (0.60) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9367104 | 0.77 | PDE3B (0.54) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL9367527 | 0.77 | PDE3B (0.55) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0280224-B1 | Substituted 3H-indoles, process for their preparation and medicines containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-06-01 | — | — | EP | disclosed |