Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 10/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29406766 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL29566071 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL29565771 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL29423343 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL29478433 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL9367335 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL9366479 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL9370827 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL9367469 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 | |
| SCHEMBL29396589 | 1.00 | BRS3 (0.77) | BRS3GAAPTGS1PTGS2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445039-B1 | Pyridylsulfonylurea and pyridylsulfonylthiourea derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-06-08 | — | — | EP | disclosed |
| US-5166162-A | Cardiovascular disorders, hypotensive agents and antiedema agents | ADIR ET COMPAGNIE (FR) | 1992-11-24 | — | — | US | disclosed |