Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 13/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368724 | 1.00 | HMGCR (0.63) | HMGCR | |
| SCHEMBL9369549 | 1.00 | HMGCR (0.63) | HMGCR | |
| SCHEMBL9691711 | 1.00 | HMGCR (0.63) | HMGCR | |
| SCHEMBL9368715 | 1.00 | HMGCR (0.63) | HMGCR | |
| SCHEMBL9369980 | 0.87 | HMGCR (0.62) | HMGCR | |
| SCHEMBL9368661 | 0.87 | HMGCR (0.62) | HMGCR | |
| SCHEMBL9368653 | 0.87 | HMGCR (0.62) | HMGCR | |
| SCHEMBL9693210 | 0.87 | HMGCR (0.62) | HMGCR | |
| SCHEMBL9368656 | 0.87 | HMGCR (0.62) | HMGCR | |
| SCHEMBL9369984 | 0.87 | HMGCR (0.62) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252476-B1 | Trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)-ethyl]- or ethenyl] tetrahydro-4-hydroxypyran-2-one-derivatives a process for their preparation and the use thereof | WARNER LAMBERT CO (US) | 1994-02-02 | — | — | EP | claimed |
| EP-0252476-A2 | Trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)-ethyl]- or ethenyl] tetrahydro-4-hydroxypyran-2-one-derivatives a process for their preparation and the use thereof | WARNER-LAMBERT COMPANY (US) | 1988-01-13 | — | — | EP | claimed |
| EP-0252476-A2 | Trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)-ethyl]- or ethenyl] tetrahydro-4-hydroxypyran-2-one-derivatives a process for their preparation and the use thereof | WARNER-LAMBERT COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |