Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 14/20 | 0.78 |
| ▸ | MELK | Q14680 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 4/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1049621 | 0.90 | PRKD1 (0.80) | PRKD1MELKFLT3MAP4K1KDR | |
| SCHEMBL6922963 | 0.88 | PRKD1 (1.00) | PRKD1MELKFLT3MAP4K1KDR | |
| SCHEMBL958990 | 0.88 | PRKD1 (1.00) | PRKD1MELKFLT3MAP4K1KDR | |
| SCHEMBL1056529 | 0.87 | PRKD1 (0.78) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL1081001 | 0.86 | PRKD1 (0.73) | PRKD1MELKFLT3MAP4K1KDR | |
| SCHEMBL6924262 | 0.86 | PRKD1 (1.00) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL1047632 | 0.86 | PRKD1 (1.00) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL936181 | 0.85 | PRKD1 (1.00) | PRKD1MELKFLT3MAP4K1 | |
| SCHEMBL6924673 | 0.84 | PRKD1 (0.76) | PRKD1MELKFLT3 | |
| SCHEMBL1083327 | 0.84 | PRKD1 (1.00) | PRKD1MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |