Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.62 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375127 | 0.93 | ROCK1 (0.64) | ROCK1ROCK2FAAHCNR2ALDH1A1 | |
| SCHEMBL9370973 | 0.89 | ROCK1 (0.55) | ROCK1ROCK2ALDH1A1PKMPOLB | |
| SCHEMBL9371842 | 0.85 | ROCK1 (0.69) | ROCK1ROCK2FAAHCNR2ALDH1A1 | |
| SCHEMBL9371121 | 0.84 | ROCK1 (0.62) | ROCK1ROCK2FAAHCNR2MAPT | |
| SCHEMBL9706553 | 0.84 | ABL1 (0.58) | ROCK1ROCK2FAAHCNR2ALDH1A1 | |
| SCHEMBL9371475 | 0.84 | ROCK1 (0.54) | ROCK1ROCK2FAAHCNR2ALDH1A1 | |
| SCHEMBL9374885 | 0.83 | ROCK1 (0.61) | ROCK1ROCK2FAAHCNR2ALDH1A1 | |
| SCHEMBL9370963 | 0.83 | ROCK1 (0.61) | ROCK1ROCK2FAAHCNR2ALDH1A1 | |
| SCHEMBL9370393 | 0.83 | ROCK1 (0.61) | ROCK1ROCK2FAAHCNR2ALDH1A1 | |
| SCHEMBL9376208 | 0.82 | ROCK1 (0.51) | ROCK1ROCK2ALDH1A1PKMPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |