Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | BLVRB | P30043 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL937399 | 1.00 | CA1 (0.52) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL6923187 | 1.00 | CA1 (0.52) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL11701793 | 0.81 | CA1 (0.59) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL23535710 | 0.79 | ESR1 (0.53) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL28713777 | 0.79 | ESR1 (0.53) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL23535712 | 0.79 | ESR1 (0.53) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL30268239 | 0.78 | KDM4E (0.67) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL330378 | 0.78 | KDM4E (0.67) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL10541064 | 0.77 | KDM4E (0.64) | CA1CA2KDM4EPTGS2CA12 | |
| SCHEMBL10546163 | 0.77 | KDM4E (0.64) | CA1CA2KDM4EPTGS2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |