Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | OPA1 | O60313 | 1/20 | 0.57 |
| ▸ | EIF5B | O60841 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373669 | 1.00 | IDO1 (0.59) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL9374648 | 1.00 | IDO1 (0.59) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL9373660 | 1.00 | IDO1 (0.59) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL27727009 | 0.89 | IDO1 (0.52) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL3689556 | 0.78 | OPA1 (0.88) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL2344229 | 0.78 | OPA1 (0.88) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL3689562 | 0.78 | OPA1 (0.88) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL12449597 | 0.78 | OPA1 (0.88) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL12808552 | 0.78 | OPA1 (0.88) | IDO1LMNAOPA1EIF5BMET | |
| SCHEMBL13241026 | 0.78 | OPA1 (0.88) | IDO1LMNAOPA1EIF5BMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630241-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | claimed |
| WO-1993018765-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | claimed |
| EP-0630241-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018765-A1 | INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |