Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 16/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.58 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375247 | 1.00 | HPGD (0.68) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL9372921 | 0.94 | HPGD (0.67) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL9372915 | 0.94 | HPGD (0.67) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL9375919 | 0.90 | HPGD (0.65) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL9375916 | 0.90 | HPGD (0.65) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL9371962 | 0.84 | PIM1 (0.65) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL9371966 | 0.84 | PIM1 (0.65) | HPGDPIM1PIM3PIM2MAOA | |
| SCHEMBL9372291 | 0.82 | PIM1 (0.65) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL9372289 | 0.82 | PIM1 (0.65) | HPGDPIM1PIM3PIM2PTPN1 | |
| SCHEMBL6866151 | 0.81 | HPGD (1.00) | HPGDPIM1PIM2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332331-B1 | Thiazolidinedione hypoglycemic agents | PFIZER (US) | 1994-02-09 | — | — | EP | disclosed |
| US-5223522-A | Anticholesterol agents | PFIZER INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5120754-A | Anticholesterol and antidiabetic agents | PFIZER INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5061717-A | ANTICHOLESTEROL AGENTS | PFIZER INC. (US) | 1991-10-29 | — | — | US | disclosed |
| WO-1989008650-A1 | THIAZOLIDINEDIONE HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332331-A2 | Thiazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1989-09-13 | — | — | EP | disclosed |