Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14893142 | 0.94 | TLR8 (0.40) | CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL9376060 | 0.92 | MAPT (0.42) | CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL9375957 | 0.85 | S1PR1 (0.36) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23612077 | 0.84 | TSHR (0.37) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL30019411 | 0.84 | TSHR (0.37) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL10286023 | 0.79 | CYP1A2 (0.41) | CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL1150368 | 0.75 | SIRT2 (0.44) | TLR8MEN1KMT2ARAB9AMAPT | |
| SCHEMBL30166980 | 0.75 | SIRT2 (0.44) | TLR8MEN1KMT2ARAB9AMAPT | |
| SCHEMBL13021084 | 0.75 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL21240900 | 0.73 | KCNH2 (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1025998-C | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-09-28 | — | — | CN | disclosed |
| EP-0379314-B1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5169947-A | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5051412-A | Pharmaceutically active 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1991-09-24 | — | — | US | disclosed |
| CN-1044465-A | 3-(1,2,5, the 6-tetrahydro pyridyl)-pyrrolopyridine | PFIZER (US) | 1990-08-08 | — | — | CN | disclosed |
| WO-1990007926-A1 | 3-(1,2,5,6-TETRAHYDROPYRIDYL)-PYRROLOPYRIDINES | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| EP-0379314-A1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1990-07-25 | — | — | EP | disclosed |