Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MIF | P14174 | 7/20 | 0.56 |
| ▸ | CD74 | P04233 | 4/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.54 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860677 | 0.84 | P2RX4 (0.68) | POLBMIFMAPK1KMT2AP2RX4 | |
| SCHEMBL16565537 | 0.84 | MIF (0.76) | POLBMIFCD74KMT2A | |
| SCHEMBL2866988 | 0.83 | MEN1 (0.56) | POLBMIFCD74PLA2G10TSHR | |
| SCHEMBL26124443 | 0.81 | IDO1 (0.57) | MIFCD74 | |
| SCHEMBL9371190 | 0.80 | MIF (0.71) | POLBMIFCD74KMT2A | |
| SCHEMBL7324840 | 0.80 | MIF (0.55) | POLBMIFCD74MAPK1P2RX4 | |
| SCHEMBL2859999 | 0.80 | KDM4E (0.53) | POLBMIFCD74TSHRMAPK1 | |
| SCHEMBL1522607 | 0.79 | MIF (0.66) | POLBMIFCD74MAPK1KMT2A | |
| SCHEMBL2862612 | 0.79 | IDO1 (0.56) | DRD4 | |
| SCHEMBL3471153 | 0.78 | KMT2A (0.68) | PLA2G2APLA2G10TSHRMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353778-B1 | Pyrrolo[1,4]benzodiazepine derivatives | SHIONOGI & CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-4923984-A | TREATMENT OF SENILE DEMENTIA, PSYCHONEUROSIS, AMNESIA | SHIONOGI & CO., LTD. (JP) | 1990-05-08 | — | — | US | disclosed |
| EP-0353778-A2 | Pyrrolo[1,4]benzodiazepine derivatives | SHIONOGI & CO., LTD. (JP) | 1990-02-07 | — | — | EP | disclosed |