Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499244 | 0.89 | CYP2C19 (0.53) | CYP2C19LMNAKMT2ACYP1A2GAA | |
| SCHEMBL7602483 | 0.86 | CYP2C19 (0.45) | CYP2C19LMNAKMT2ACYP1A2GAA | |
| SCHEMBL7503286 | 0.85 | CYP2C19 (0.51) | CYP2C19LMNAKMT2ACYP1A2GAA | |
| SCHEMBL25347026 | 0.85 | CYP2C19 (0.46) | CYP2C19LMNAKMT2ACYP1A2GAA | |
| SCHEMBL2728552 | 0.83 | CYP1A2 (0.47) | CYP2C19LMNAKMT2ACYP1A2GAA | |
| SCHEMBL2728549 | 0.83 | CYP1A2 (0.47) | CYP2C19LMNAKMT2ACYP1A2GAA | |
| SCHEMBL2732414 | 0.83 | MAPT (0.48) | CYP2C19LMNACYP1A2GAAMAPT | |
| SCHEMBL796491 | 0.80 | CYP2C19 (0.46) | CYP2C19LMNAKMT2ACYP1A2GAA | |
| SCHEMBL1645440 | 0.79 | NPC1 (0.42) | CYP2C19KMT2ACYP1A2GAAMAPT | |
| SCHEMBL16814418 | 0.78 | CYP2C19 (0.51) | CYP2C19LMNAKMT2ACYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379314-B1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5169947-A | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5051412-A | Pharmaceutically active 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1991-09-24 | — | — | US | disclosed |