Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA7 | P43166 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211424 | 0.82 | MAPT (0.47) | MAPTCHEK1METGSK3BLIMK1 | |
| SCHEMBL1617947 | 0.78 | MAPT (0.45) | MAPTCHEK1METGSK3BLIMK1 | |
| SCHEMBL8243303 | 0.78 | MAPT (0.45) | MAPTCHEK1METGSK3BLIMK1 | |
| SCHEMBL8493851 | 0.77 | CHEK1 (0.41) | MAPTCHEK1METGSK3BLIMK1 | |
| SCHEMBL6994913 | 0.77 | CA12 (0.42) | MAPTCHEK1METGSK3BLIMK1 | |
| Hydrochloric Acid SCHEMBL1617128 | 0.77 | MAPT (0.44) | MAPTCHEK1METGSK3BLIMK1 | |
| SCHEMBL30461811 | 0.77 | MAPT (0.44) | MAPTCHEK1METGSK3BLIMK1 | |
| SCHEMBL12733115 | 0.76 | MAPT (0.42) | MAPTCHEK1METGSK3BLIMK1 | |
| SCHEMBL12806874 | 0.76 | HPGD (0.54) | MAPTLMNAGAAKDM4ETDP1 | |
| SCHEMBL7355060 | 0.74 | MAPT (0.49) | MAPTCHEK1METGSK3BLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0371594-B1 | Thiophene-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1994-02-16 | — | — | EP | disclosed |
| US-5015656-A | Antidepressants, anxiolytic compounds, central nervous system active compounds for psychotic conditions, aminoalkylcarboxami de derivatives of thiophene | LILLY S.A. (ES) | 1991-05-14 | — | — | US | disclosed |
| EP-0371594-A1 | Thiophene-carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1990-06-06 | — | — | EP | disclosed |