Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9375894 | 0.82 | RXFP1 (0.47) | TP53MAPTRXFP1POLBLMNA | |
| SCHEMBL3499006 | 0.81 | TP53 (0.44) | TP53MAPTRXFP1POLBCSNK1D | |
| SCHEMBL3497078 | 0.81 | TP53 (0.46) | TP53MAPTRXFP1MEN1KMT2A | |
| SCHEMBL9374217 | 0.80 | TP53 (0.43) | TP53MAPTRXFP1NPC1RAB9A | |
| SCHEMBL3498533 | 0.77 | KDM4E (0.61) | RXFP1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL9374502 | 0.76 | KDR (0.50) | NPC1RAB9AKDM4ECSNK1DRIPK1 | |
| SCHEMBL10532315 | 0.76 | NPC1 (0.70) | TP53MAPTRXFP1MEN1KMT2A | |
| SCHEMBL8966075 | 0.74 | RXFP1 (0.44) | TP53MAPTRXFP1NPC1RAB9A | |
| SCHEMBL19925108 | 0.73 | KMT2A (0.47) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL253680 | 0.73 | CSNK1D (0.44) | NPC1RAB9AKDM4ECSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305093-B1 | Imidazo(1,2-b)pyridazine derivatives | WELLCOME FOUND (GB) | 1994-04-06 | — | — | EP | disclosed |