SCHEMBL9378178

SCHEMBL9378178

Nc1cc(N2CCc3ccccc32)ncn1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK1 Q13464 2/20 0.56
SMN1; SMN2 Q16637 4/20 0.48
HTT P42858 1/20 0.48
LMNA P02545 1/20 0.47
TP53 P04637 1/20 0.47
MAPK1 P28482 1/20 0.47
EGFR P00533 2/20 0.46
HPGD P15428 4/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
RXFP1 Q9HBX9 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HSD17B10 Q99714 4/20 0.46
KDM4E B2RXH2 2/20 0.46
MAPT P10636 2/20 0.46
CSF1R P07333 1/20 0.45
NPSR1 Q6W5P4 1/20 0.43
NUDT1 P36639 1/20 0.42
RXRA P19793 1/20 0.41
RXRB P28702 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16071242 0.91 ROCK1 (0.58) ROCK1SMN1; SMN2HTTLMNATP53
SCHEMBL6762394 0.83 ROCK1 (0.51) ROCK1SMN1; SMN2HTTLMNATP53
SCHEMBL9379055 0.77 ROCK1 (0.55) ROCK1SMN1; SMN2HTTLMNATP53
SCHEMBL9379977 0.76 ROCK1 (0.61) ROCK1SMN1; SMN2HTTLMNATP53
SCHEMBL28609745 0.75 ROCK1 (0.60) ROCK1SMN1; SMN2HTTLMNATP53
SCHEMBL30362762 0.75 ROCK1 (0.53) ROCK1SMN1; SMN2LMNATP53MAPK1
SCHEMBL28667775 0.75 ROCK1 (0.53) ROCK1SMN1; SMN2LMNATP53MAPK1
SCHEMBL31218789 0.74 ROCK1 (0.58) ROCK1SMN1; SMN2HTTLMNATP53
SCHEMBL6071629 0.73 ROCK1 (0.62) ROCK1SMN1; SMN2LMNATP53MAPK1
SCHEMBL29721478 0.73 ROCK1 (0.62) ROCK1SMN1; SMN2LMNATP53MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190240195-A1 METHODS OF TREATING MUSCULAR DYSTROPHY Board of Regents of the Nevada System of Higher Education, on behalf of the Univ of Nevada, Reno (US) 2019-08-08 US disclosed
US-10206903-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2019-02-19 US disclosed
US-9980943-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEMS OF HIGHER EDUCATION ON BEHALF OF THE NEVADA, RENO (US) 2018-05-29 US disclosed
US-9980943-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEMS OF HIGHER EDUCATION ON BEHALF OF THE NEVADA, RENO (US) 2018-05-29 US disclosed
US-20170340606-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, (US) 2017-11-30 US disclosed
US-20170340606-A1 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, (US) 2017-11-30 US disclosed
US-9707210-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2017-07-18 US disclosed
US-9707210-B2 Methods of treating muscular dystrophy BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2017-07-18 US disclosed
US-20160030390-A1 METHODS OF TREATING MUSCULAR DYSTROPHY Board of Regents of the Nevada System of Higher Ed ucation on behalf of the University of Nevada Ren (US) 2016-02-04 US disclosed
US-20160030390-A1 METHODS OF TREATING MUSCULAR DYSTROPHY Board of Regents of the Nevada System of Higher Ed ucation on behalf of the University of Nevada Ren (US) 2016-02-04 US disclosed
WO-2014144606-A2 METHODS OF TREATING MUSCULAR DYSTROPHY BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) 2014-09-18 WO disclosed
EP-0422178-B1 PYRIMIDINE DERIVATIVES ZENECA LTD (GB) 1994-10-05 EP disclosed
US-5223505-A PYRIMIDINE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-06-29 US disclosed
EP-0422178-A1 PYRIMIDINE DERIVATIVES. ICI PLC (GB) 1991-04-17 EP disclosed
WO-1990012790-A1 PYRIMIDINE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-11-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190240195-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 ROCK1 2510/4885SMN1; SMN2 22/4885HTT 4298/4885
US-10206903-B2 Methods of treating muscular dystrophy ITGB7, ITGA2B, ITGB1 ROCK1 2510/4885SMN1; SMN2 22/4885HTT 4298/4885
US-20170340606-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 ROCK1 2510/4885SMN1; SMN2 22/4885HTT 4298/4885
US-20160030390-A1 METHODS OF TREATING MUSCULAR DYSTROPHY ITGB7, ITGA2B, ITGB1 ROCK1 2510/4885SMN1; SMN2 22/4885HTT 4298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.