Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378441 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1POLBRAB9ALMNA | |
| SCHEMBL9379764 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1POLBRAB9ALMNA | |
| SCHEMBL11153088 | 0.77 | GAA (0.44) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL11153086 | 0.77 | GAA (0.44) | SMN1; SMN2NPC1RAB9AALDH1A1GAA | |
| SCHEMBL10468368 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1POLBRAB9ALMNA | |
| SCHEMBL4683990 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1POLBRAB9ALMNA | |
| SCHEMBL10468597 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1POLBRAB9ALMNA | |
| SCHEMBL4683993 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1POLBRAB9ALMNA | |
| SCHEMBL4678075 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1POLBRAB9ALMNA | |
| SCHEMBL4678079 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1POLBRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306696-B1 | Substituted guanidines | CIBA GEIGY AG (CH) | 1994-02-16 | — | — | EP | claimed |
| EP-0306696-B1 | Substituted guanidines | CIBA GEIGY AG (CH) | 1994-02-16 | — | — | EP | disclosed |