Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367014 | 0.83 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7366444 | 0.81 | PDE4A (0.59) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7362628 | 0.80 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL9375608 | 0.79 | PDE4A (0.57) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7361132 | 0.78 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL9379010 | 0.75 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7370523 | 0.75 | PDE4A (0.53) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7363644 | 0.75 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7366898 | 0.75 | PDE4A (0.69) | PDE4APDE4DPDE4BPDE4CPDE3B | |
| SCHEMBL7369778 | 0.73 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |