Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.62 |
| ▸ | GPR52 | Q9Y2T5 | 10/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10912747 | 0.84 | GRIK1 (0.64) | GRIK1GPR52ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL800576 | 0.84 | GRIK1 (0.64) | GRIK1GPR52ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL5727501 | 0.81 | CYP2C9 (0.46) | GRIK1ALDH1A1CYP3A4CYP2C9KEAP1 | |
| SCHEMBL10705265 | 0.81 | CYP2C9 (0.46) | GRIK1ALDH1A1CYP3A4CYP2C9KEAP1 | |
| SCHEMBL9943873 | 0.80 | GRIK1 (0.49) | GRIK1GPR52ALDH1A1HDAC3MAPK1 | |
| SCHEMBL197321 | 0.78 | GRIK1 (0.53) | GRIK1GPR52ALDH1A1CYP2C9KEAP1 | |
| SCHEMBL197322 | 0.78 | GRIK1 (0.53) | GRIK1GPR52ALDH1A1CYP2C9KEAP1 | |
| SCHEMBL8218335 | 0.77 | GRIK1 (0.56) | GRIK1GPR52ALDH1A1KEAP1HDAC3 | |
| SCHEMBL22607727 | 0.77 | GRIK1 (0.56) | GRIK1GPR52ALDH1A1KEAP1HDAC3 | |
| SCHEMBL8404626 | 0.77 | GRIK1 (1.00) | GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |