Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | HCK | P08631 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3189520 | 0.84 | KDM4E (0.43) | PIK3C3ABL1PIK3CDEGFRHCK | |
| SCHEMBL14826051 | 0.78 | PIK3C3 (0.51) | PIK3C3DYRK1AABL1PIK3CDEGFR | |
| SCHEMBL3196029 | 0.77 | DYRK1A (0.58) | PIK3C3DYRK1AABL1PIK3CDEGFR | |
| SCHEMBL3194422 | 0.77 | PIK3C3 (0.51) | PIK3C3DYRK1AABL1PIK3CDEGFR | |
| SCHEMBL10174938 | 0.73 | PIK3C3 (0.44) | PIK3C3DYRK1AABL1PIK3CDEGFR | |
| SCHEMBL5252715 | 0.73 | KDR (0.50) | PIK3C3DYRK1AABL1PIK3CDEGFR | |
| SCHEMBL11925796 | 0.73 | FGFR3 (0.42) | PIK3C3KDROGAMAPK1 | |
| SCHEMBL29676973 | 0.73 | PIK3C3 (0.39) | PIK3C3DYRK1AABL1PIK3CDEGFR | |
| SCHEMBL3190030 | 0.73 | PIK3C3 (0.39) | PIK3C3DYRK1AABL1PIK3CDEGFR | |
| SCHEMBL11925504 | 0.73 | PIK3C3 (0.39) | PIK3C3DYRK1AABL1PIK3CDEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588859-A1 | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | claimed |
| WO-1992022553-A1 | IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[3,2-d]AZEPINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | claimed |