Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 12/20 | 0.85 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.85 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.85 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936438 | 0.92 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL6924103 | 0.92 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL936439 | 0.92 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL936479 | 0.91 | PRKD1 (0.81) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL6923622 | 0.90 | PRKD1 (0.80) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL935616 | 0.90 | PRKD1 (0.79) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL6924074 | 0.89 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL6923883 | 0.87 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL935676 | 0.85 | PRKD1 (0.88) | PRKD1PRKD3PRKD2ATMATR | |
| SCHEMBL937974 | 0.83 | PRKD1 (0.72) | PRKD1PRKD3PRKD2ATMATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |