Tyrphostin Ag-1478

Tyrphostin Ag-1478

SCHEMBL93838

COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 13/20 1.00
KDM4E B2RXH2 3/20 1.00
MAPT P10636 3/20 1.00
MAPK1 P28482 3/20 1.00
FBP1 P09467 3/20 1.00
SRC P12931 3/20 1.00
ABL1 P00519 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 2/20 1.00
CYP2D6 P10635 2/20 1.00
MAPK14 Q16539 2/20 1.00
MKNK1 Q9BUB5 2/20 1.00
MEN1 O00255 1/20 1.00
GMNN O75496 1/20 1.00
ALDH1A1 P00352 1/20 1.00
LMNA P02545 1/20 1.00
RAF1 P04049 1/20 1.00
TP53 P04637 1/20 1.00
GLA P06280 1/20 1.00
HPGD P15428 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrphostin Ag-1478 SCHEMBL31079458 1.00 EGFR (1.00) EGFRKDM4EMAPTMAPK1FBP1
Tyrphostin Ag-1478 SCHEMBL29483198 1.00 EGFR (1.00) EGFRKDM4EMAPTMAPK1FBP1
Tyrphostin Ag-1478 SCHEMBL29350062 1.00 EGFR (1.00) EGFRKDM4EMAPTMAPK1FBP1
Tyrphostin Ag-1478 SCHEMBL30362802 0.99 EGFR (1.00) EGFRKDM4EMAPTMAPK1FBP1
Tyrphostin Ag-1478 SCHEMBL5477838 0.99 EGFR (1.00) EGFRKDM4EMAPTMAPK1FBP1
Tyrphostin Ag-1478 SCHEMBL31466723 0.99 EGFR (1.00) EGFRKDM4EMAPTMAPK1FBP1
SCHEMBL21982440 0.94 EGFR (0.89) EGFRKDM4EMAPTMAPK1FBP1
SCHEMBL8258194 0.91 EGFR (0.83) EGFRKDM4EMAPTMAPK1FBP1
SCHEMBL18158234 0.91 EGFR (0.83) EGFRKDM4EMAPTMAPK1FBP1
SCHEMBL1417950 0.90 EGFR (0.82) EGFRKDM4EMAPTMAPK1FBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2968 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107237-A1 RAS AND EGFR INHIBITORS COMBINATION THERAPY ERASCA, INC. (US) 2026-05-21 WO claimed
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
EP-4743490-A1 HUMANIZED ANTI-CD7 ANTIBODY Christian-Albrechts-Universität zu Kiel (DE) 2026-05-20 EP claimed
WO-2026099502-A1 NOVEL DRUG CONJUGATES FOR TESTING CELLULAR DRUG UPTAKE Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2026-05-15 WO claimed
US-20260076961-A1 COMBINATION TREATMENTS Celex Oncology Innovations Limited (GB) 2026-03-19 US claimed
EP-4687999-A1 TROP2 CONJUGATED BIOLOGICAL MOLECULES, PHARMACEUTICAL COMPOSITIONS AND METHODS OBI Pharma, Inc. (TW) 2026-02-11 EP claimed
EP-4676544-A1 ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODIES AGAINST HUMAN L1CAM AND USES THEREOF LigaChem Biosciences Inc. (KR) 2026-01-14 EP claimed
US-20250319110-A1 SURFACE CALR CHEMICAL INDUCERS ZON LEONARD (US) 2025-10-16 US claimed
EP-4615869-A1 COMBINATION THERAPY COMPRISING BISPECIFIC ANTIBODIES COMPRISING AN NRP1 BINDING DOMAIN Pinetree Therapeutics, Inc. (US) 2025-09-17 EP claimed
US-20250242043-A1 ANTIBODY-DRUG CONJUGATE COMPRISING ANTIBODY AGAINST HUMAN TROP2 AND USE THEREOF LIGACHEM BIOSCIENCES, INC. (KR) 2025-07-31 US claimed
US-20040127470-A1 Methods and compositions for the prevention or treatment of neoplasia comprising a Cox-2 inhibitor in combination with an epidermal growth factor receptor antagonist PHARMACIA CORPORATION (US) 2004-07-01 US claimed
US-20020156023-A1 Lometrexol combination therapy TULARIK INC. 2002-10-24 US claimed
WO-2002045717-A1 LOMETREXOL COMBINATION THERAPY TULARIK INC. (US) 2002-06-13 WO claimed
EP-1156775-A1 REDUCTION OF HAIR GROWTH THE GILLETTE COMPANY (US) 2001-11-28 EP claimed
US-6121269-A TOPICALLY APPLYING A PROTEIN-TYROSINE KINASE INHIBITOR TO SKIN TO REDUCE ANDROGEN-STIMULATED HAIR GROWTH WITHOUT SIDE EFFECTS GILLETTE COMPANY, THE, A DELAWARE CORPORATION 2000-09-19 US claimed
WO-2000050002-A1 REDUCTION OF HAIR GROWTH THE GILLETTE COMPANY (US) 2000-08-31 WO claimed
US-6004967-A TOPICALLY ADMINISTERING 4-(3-BROMOPHENYLAMINO)-6,7-DIMETHOXYQUINAZOLINE TO TREAT HYPERPROLIFERATION CAUSED BY PAPILLOMAVIRUS INFECTION SUGEN, INC. (US) 1999-12-21 US claimed
EP-0954315-A2 USE OF QUINAZOLINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT IN THE TREATMENT OF HYPERPROLIFERATIVE SKIN DISORDERS Sugen, Inc. (US) 1999-11-10 EP claimed
WO-1998010767-A9 USE OF QUINAZOLINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT IN THE TREATMENT OF HYPERPROLIFERATIVE SKIN DISORDERS 1998-07-02 WO claimed
WO-1998010767-A2 USE OF QUINAZOLINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT IN THE TREATMENT OF HYPERPROLIFERATIVE SKIN DISORDERS SUGEN, INC. (US) 1998-03-19 WO claimed