Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9385284 | 1.00 | CDK2 (0.51) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL9384217 | 0.98 | CDK2 (0.53) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| Oxalic Acid SCHEMBL9384819 | 0.96 | MAPT (0.49) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| Oxalic Acid SCHEMBL9384824 | 0.96 | MAPT (0.49) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL9384185 | 0.94 | MAPT (0.51) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| Oxalic Acid SCHEMBL9383591 | 0.91 | MAPT (0.44) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| Oxalic Acid SCHEMBL9383584 | 0.91 | MAPT (0.44) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL9388630 | 0.88 | MAPT (0.46) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL9382923 | 0.84 | MAPT (0.47) | CDK2ALDH1A1KMT2AMAPTMEN1 | |
| Oxalic Acid SCHEMBL9383577 | 0.84 | CYP19A1 (0.46) | CDK2ALDH1A1KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369627-B1 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5008267-A | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0369627-A2 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-05-23 | — | — | EP | disclosed |