Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259549 | 0.89 | HTR2A (0.44) | HTR2AHTR2CNOTUMRPS6KA3L3MBTL1 | |
| SCHEMBL14387287 | 0.79 | HTR2A (0.41) | HTR2AHTR2CNOTUMRPS6KA3KDM4E | |
| SCHEMBL3083411 | 0.76 | RPS6KA3 (0.52) | RPS6KA3CYP1A2ALDH1A1RPS6KA2 | |
| SCHEMBL28028081 | 0.76 | RPS6KA3 (0.65) | RPS6KA3RPS6KA2 | |
| SCHEMBL30622473 | 0.76 | RPS6KA3 (0.65) | RPS6KA3RPS6KA2 | |
| SCHEMBL2019621 | 0.74 | MAOB (0.51) | CYP1A2ALDH1A1KMT2A | |
| SCHEMBL28922791 | 0.74 | CYP1A2 (0.36) | RPS6KA3CYP1A2KDM4EUSP2ALDH1A1 | |
| SCHEMBL30148885 | 0.74 | CYP1A2 (0.36) | RPS6KA3CYP1A2KDM4EUSP2ALDH1A1 | |
| SCHEMBL761931 | 0.74 | HTR2A (0.64) | HTR2AHTR2CNOTUMKDM4EALDH1A1 | |
| SCHEMBL30703022 | 0.74 | HTR2A (0.64) | HTR2AHTR2CNOTUMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384349-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1994-04-27 | — | — | EP | disclosed |
| EP-0384349-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |