Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.71 |
| ▸ | NOS2 | P35228 | 5/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BHMT | Q93088 | 3/20 | 0.46 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.46 |
| ▸ | ARG2 | P78540 | 4/20 | 0.46 |
| ▸ | ARG1 | P05089 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL27480207 | 1.00 | GSR (0.71) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL10491088 | 1.00 | GSR (0.71) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL1345091 | 1.00 | GSR (0.71) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL8720001 | 1.00 | GSR (0.71) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL1345092 | 1.00 | GSR (0.71) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL6574898 | 0.98 | GSR (0.69) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL6665159 | 0.98 | GSR (0.69) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL27579522 | 0.98 | GSR (0.69) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL6574892 | 0.98 | GSR (0.69) | GSRNOS2NOS1NOS3CYP2C19 | |
| Lysine SCHEMBL27667352 | 0.98 | GSR (0.69) | GSRNOS2NOS1NOS3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2842575-B1 | Auristatin drug linker conjugates | SEATTLE GENETICS INC (US) | 2017-09-27 | — | — | EP | disclosed |
| US-9463252-B2 | Auristatin drug linker conjugates | SEATTLE GENETICS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| EP-2842575-A1 | Auristatin drug linker conjugates | Seattle Genetics, Inc. (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2265283-B1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS INC (US) | 2014-09-03 | — | — | EP | disclosed |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8609105-B2 | Auristatin drug linker conjugates | SEATTLE GENETICS, INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-4837004-A | PROTECTIVE POLYMER COATING | EASTMAN KODAK COMPANY (US) | 1989-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | GSR 3767/4885NOS2 3975/4885NOS1 4076/4885 |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | GSR 3767/4885NOS2 3975/4885NOS1 4076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.