Tiapamil

Tiapamil

SCHEMBL93936

COc1ccc(CCN(C)CCCC2(c3ccc(OC)c(OC)c3)S(=O)(=O)CCCS2(=O)=O)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 2/20 1.00
SCN2A Q99250 2/20 1.00
SCN3A Q9NY46 2/20 1.00
CYP3A4 P08684 4/20 0.54
CYP1A2 P05177 2/20 0.54
CYP2D6 P10635 2/20 0.54
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53
SMPD1 P17405 6/20 0.48
ABCB1 P08183 6/20 0.46
MAPT P10636 1/20 0.46
HCN4 Q9Y3Q4 1/20 0.46
ALOX15 P16050 1/20 0.45
AOC3 Q16853 1/20 0.43
KDM4E B2RXH2 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP2C19 P33261 2/20 0.42
ABCC1 P33527 2/20 0.42
MEN1 O00255 1/20 0.42
SLC22A1 O15245 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tiapamil SCHEMBL635113 0.99 SCN1A (0.98) SCN1ASCN2ASCN3ACYP3A4CYP1A2
Bromide SCHEMBL11615923 0.95 SCN1A (0.90) SCN1ASCN2ASCN3ACYP3A4CYP1A2
SCHEMBL25861795 0.94 SCN1A (0.89) SCN1ASCN2ASCN3ACYP3A4CYP1A2
Hydrochloric Acid SCHEMBL11607284 0.93 SCN1A (0.87) SCN1ASCN2ASCN3ACYP3A4CYP1A2
SCHEMBL11614948 0.93 SCN1A (0.86) SCN1ASCN2ASCN3ACYP3A4CYP1A2
Hydrochloric Acid SCHEMBL11613134 0.92 SCN1A (0.85) SCN1ASCN2ASCN3ACYP3A4CYP1A2
Oxalic Acid SCHEMBL11610568 0.92 SCN1A (0.85) SCN1ASCN2ASCN3ACYP3A4CYP1A2
Hydrochloric Acid SCHEMBL11613226 0.92 SCN1A (0.85) SCN1ASCN2ASCN3ACYP3A4CYP1A2
Hydrochloric Acid SCHEMBL11726187 0.92 SCN1A (0.85) SCN1ASCN2ASCN3ACYP3A4CYP1A2
Hydrochloric Acid SCHEMBL11612658 0.92 SCN1A (0.84) SCN1ASCN2ASCN3ACYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3091 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124180-A1 METHOD OF TREATING AFFECTIVE DISORDERS AND PERSONALITY DISORDERS HB BIOTECH, INC. (US) 2026-05-07 US claimed
EP-4724060-A1 FORMULATIONS AND METHODS FOR TREATING NEUROPSYCHIATRIC DISORDERS HB Biotech, Inc. (US) 2026-04-15 EP claimed
US-12539291-B2 Method of treating affective disorders and personality disorders HB BIOTECH, INC. (US) 2026-02-03 US claimed
US-20260028594-A1 CELL PATCH CRYOPRESERVATION SOLUTION AND METHOD OF CRYOPRESERVING A CELL PATCH BOE REGENERATIVE MEDICINE TECH CO LTD (CN) 2026-01-29 US claimed
US-20250152591-A1 TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS KURA ONCOLOGY INC (US) 2025-05-15 US claimed
CN-119173139-A Cell patch frozen stock solution and cell patch frozen stock method 京东方科技集团股份有限公司 2024-12-20 CN claimed
WO-2024254389-A1 FORMULATIONS AND METHODS FOR TREATING NEUROPSYCHIATRIC DISORDERS HB BIOTECH, INC. (US) 2024-12-12 WO claimed
EP-4472637-A1 TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS Kura Oncology, Inc. (US) 2024-12-11 EP claimed
US-12128031-B2 Method of improving psychosocial health HB BIOTECH, INC. (US) 2024-10-29 US claimed
WO-2024216594-A1 CELL SHEET CRYOPRESERVATION SOLUTION AND METHOD FOR CRYOPRESERVING CELL SHEET 京东方科技集团股份有限公司 2024-10-24 WO claimed
US-4808413-A MIXING DRUG, ACID, BINDER, EXTRUSION AND SPHERONIZATION E. R. SQUIBB & SONS, INC. (US) 1989-02-28 US claimed
US-4783337-A Osmotic system comprising plurality of members for dispensing drug ALZA CORPORATION (US) 1988-11-08 US claimed
EP-0288732-A2 New pharmaceutical compositions in the form of beadlets and method E.R. Squibb & Sons, Inc. (US) 1988-11-02 EP claimed
US-4782043-A HYPOTENSIVES MERCK & CO., INC. (US) 1988-11-01 US claimed
EP-0209897-A2 Peptide enzyme inhibitors MERCK & CO. INC. (US) 1987-01-28 EP claimed
US-4584294-A Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents MERCK & CO., INC. (US) 1986-04-22 US claimed
EP-0166353-A2 Benzofused lactams useful as antihypertensive agents and as cholecystokinin antagonists MERCK & CO. INC. (US) 1986-01-02 EP claimed
EP-0163237-A2 Di- and tri-peptidal renin inhibitors MERCK & CO. INC. (US) 1985-12-04 EP claimed
EP-0129189-A2 Renin inhibitors containing a C-terminal amide cycle and compositions and combinations containing the same MERCK & CO. INC. (US) 1984-12-27 EP claimed
US-4003914-A DITHIANE AND DISULFONE CORONARY DILATING AGENTS HOFFMANN-LA ROCHE INC. (US) 1977-01-18 US claimed