Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 19/20 | 0.65 |
| ▸ | PPIF | P30405 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400708 | 0.80 | HTR2B (0.66) | KDM4EMEN1TP53CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9400633 | 0.79 | HTR2C (0.67) | KDM4EMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL7660978 | 0.77 | HTR2C (0.69) | KDM4EMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9400613 | 0.76 | HTR2B (0.65) | KDM4EMEN1TP53CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8944881 | 0.75 | HTR2C (0.69) | KDM4EMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9081802 | 0.75 | HTR2B (0.58) | KDM4EMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9081096 | 0.74 | HTR2B (0.57) | KDM4EMEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL28413819 | 0.74 | NOTUM (0.49) | MEN1KMT2A | |
| SCHEMBL30779665 | 0.74 | NOTUM (0.49) | MEN1MAPTKMT2A | |
| SCHEMBL27775771 | 0.74 | MAOB (0.50) | KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328922-A | Anxiolytic and antidepressant activity | BEECHAM GROUP P.L.C. (GB) | 1994-07-12 | — | — | US | disclosed |
| WO-1993018026-A1 | INDOLE UREAS AS 5-HT1C RECEPTOR ANTOGONISTS | BEECHAM GROUP PLC (GB) | 1993-09-16 | — | — | WO | disclosed |
| EP-0550507-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005170-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |