Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400926 | 0.98 | TSHR (0.74) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL9401041 | 0.86 | TSHR (0.55) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL9401020 | 0.86 | TSHR (0.55) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL9401016 | 0.86 | TSHR (0.60) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL9400917 | 0.86 | TSHR (0.55) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL9400970 | 0.86 | TSHR (0.55) | TSHRADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL9400955 | 0.86 | TSHR (0.55) | TSHRADRA1DADRA1AADRA1BSMN1; SMN2 | |
| Pelanserin SCHEMBL1133637 | 0.85 | MEN1 (0.76) | ADRA1DADRA1AADRA1BALDH1A1MEN1 | |
| Pelanserin SCHEMBL120877 | 0.85 | MEN1 (0.79) | ADRA1DADRA1AADRA1BALDH1A1MEN1 | |
| SCHEMBL9400894 | 0.84 | TSHR (0.57) | TSHRADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| EP-0129128-B1 | 2-PYRIMIDINYL-1-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |
| EP-0129128-A2 | 2-Pyrimidinyl-1-piperazine derivatives, process for their preparation and medicines containing them | Troponwerke GmbH & Co. KG (DE) | 1984-12-27 | — | — | EP | disclosed |