Phosphine

Phosphine

SCHEMBL9401959

CNc1ccccc1C.P

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.54
HTT P42858 1/20 0.54
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
HPGD P15428 5/20 0.48
ALDH1A1 P00352 3/20 0.48
POLB P06746 5/20 0.48
KDM4E B2RXH2 3/20 0.48
TDP1 Q9NUW8 2/20 0.48
USP2 O75604 1/20 0.48
RECQL P46063 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
HSD17B10 Q99714 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
TSHR P16473 1/20 0.47
ACHE P22303 1/20 0.47
GAA P10253 2/20 0.46
SIGMAR1 Q99720 1/20 0.41
ALOX12 P18054 1/20 0.41
ADRA2C P18825 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29370546 0.97
SCHEMBL172153 0.97
Hydrochloric Acid SCHEMBL2862264 0.94 MAPT (0.54) MAPTHTTNPC1RAB9AHPGD
Phenol SCHEMBL6874450 0.84 TDP1 (0.48) MAPTHTTNPC1RAB9AHPGD
Aniline SCHEMBL28111121 0.84 TSHR (0.48) MAPTHTTNPC1RAB9AHPGD
Hypophosphorous Acid SCHEMBL5935330 0.84 NPC1 (0.52) MAPTHTTNPC1RAB9AHPGD
SCHEMBL12320094 0.82 MAPT (0.48) MAPTHTTNPC1RAB9AHPGD
SCHEMBL28663942 0.82 MAPT (0.48) MAPTHTTNPC1RAB9AHPGD
SCHEMBL31398192 0.79
SCHEMBL29449705 0.78 POLB (0.60) MAPTHTTNPC1RAB9AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5364445-A Adding a basic reactant, combustion N.E. CHEMCAT CORPORATION (JP) 1994-11-15 US disclosed