Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 13/20 | 0.73 |
| ▸ | DRD2 | P14416 | 7/20 | 0.71 |
| ▸ | DRD5 | P21918 | 5/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | THPO | P40225 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.69 |
| ▸ | GPR183 | P32249 | 1/20 | 0.69 |
| ▸ | APLNR | P35414 | 1/20 | 0.69 |
| ▸ | GLP1R | P43220 | 1/20 | 0.69 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10691156 | 0.99 | DRD1 (0.71) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| SCHEMBL10691029 | 0.98 | DRD1 (0.73) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| Bromide SCHEMBL10693960 | 0.97 | DRD1 (0.71) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| SCHEMBL10690570 | 0.85 | DRD1 (0.65) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| SCHEMBL13900335 | 0.83 | DRD1 (0.80) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| SCHEMBL8769365 | 0.83 | DRD1 (0.80) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| SCHEMBL29374870 | 0.83 | DRD1 (0.80) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| Sch-23390 SCHEMBL16187032 | 0.83 | DRD1 (1.00) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| Sch-23390 SCHEMBL2916216 | 0.83 | DRD1 (1.00) | DRD1DRD2DRD5CYP1A2CYP2D6 | |
| Sch-23390 SCHEMBL30628012 | 0.83 | DRD1 (1.00) | DRD1DRD2DRD5CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383247-B1 | Benzazepines with antidopaminergic activity | NOVO NORDISK AS (DK) | 1994-08-03 | — | — | EP | disclosed |
| US-5079243-A | Nervous System Disorders, Antidopaminergic Effect | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |
| EP-0383247-A1 | Benzazepines with antidopaminergic activity | NOVO NORDISK A/S (DK) | 1990-08-22 | — | — | EP | disclosed |